Journal
BIOESSAYS
Volume 30, Issue 11-12, Pages 1185-1192Publisher
WILEY
DOI: 10.1002/bies.20836
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Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder of motor neurones. Although the genetic basis of familial forms of AILS has been well explored, the molecular basis of sporadic AILS is less well understood. Recent evidence has linked sporadic AILS with the failure to edit key residues in ionotropic glutamate receptors, resulting in excessive influx of calcium ions into motor neurones which in turn triggers cell death. Here we suggest that edited AMPA glutamate (GluR2) receptor subunits serve as gatekeepers for motor neurone survival. BioEssays 30:1185-1192, 2008. (C) 2008 Wiley Periodicals, Inc.
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