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Why Helicobacter pylori has Lewis antigens

Journal

TRENDS IN MICROBIOLOGY
Volume 8, Issue 12, Pages 565-570

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/S0966-842X(00)01875-8

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In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

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