Journal
BIOELECTROCHEMISTRY
Volume 88, Issue -, Pages 156-163Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2012.03.006
Keywords
Graphene; Copper oxide nanocubes; Glucose; Electrodeposition; Nonenzymatic sensor
Funding
- National Science Foundation of China [20875087, 41140031, 61171033]
- Leading Academic Discipline Project of Shanghai Municipal Education Commission [J50102]
- National Basic Research Program of China [2011CB935800]
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Here, we report a nonenzymatic amperometric glucose sensor based on copper oxide (CuO) nanocubes-graphene nanocomposite modified glassy carbon electrode (CuO-G-GCE). In this case, the graphene sheets were cast on the GCE directly. CuO nanocubes were obtained by oxidizing electrochemically deposited Cu on the graphene. The morphology of CuO-G nanocomposite was characterized by scanning electron microscopy. The CuO-G-GCE-based sensor exhibited excellent electrocatalytic activity and high stability for glucose oxidation. Under optimized conditions, the linearity between the current response and the glucose concentration was obtained in the range of 2 mu M to 4 mM with a detection limit 01 0.7 mu M (S/N = 3), and a high sensitivity of 1360 mu A mM(-1) cm(-2). The proposed electrode showed a fast response time (less than 5 s) and a good reproducibility. The as-made sensor was applied to determine the glucose levels in clinic human serum samples with satisfactory results. In addition, the effects of common interfering species, including ascorbic acid, uric acid, dopamine and other carbohydrates, on the amperometric response of the sensor were investigated and discussed in detail. (C) 2012 Elsevier B.V. All rights reserved.
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