Journal
BIOELECTROCHEMISTRY
Volume 80, Issue 1, Pages 94-98Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2010.08.006
Keywords
Electronic tongue; Active pharmaceutical substances; Taste masking; Encapsulation
Ask authors/readers for more resources
Electronic tongues can produce chemical images of samples, whose changes can be correlated with general properties, e.g. taste sensations. In this work, a sensor array equipped with eight types of ion-selective electrodes was coupled with Principal Components Analysis in order to detect microencapsulation effect of two Active Pharmaceutical Ingredients (APIs), which influences their taste properties. The character of change of sensor array responses in samples modified by microencapsulation was the same in two investigated APIs (Ibuprofen and Rixithromycin), proving, that the sensed taste becomes similar in both formulations after Eudragit modification. The obtained results show, that the presented electronic tongue can be used for analysis of masking effects in drugs and detection of microencapsulation effect. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available