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The immunogenicity of humanized and fully human antibodies Residual immunogenicity resides in the CDR regions
Fiona A. Harding et al.
MABS (2010)
Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties
G. Wozniak-Knopp et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2010)
Stability engineering of scFvs for the development of bispecific and multivalent antibodies
Brian R. Miller et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2010)
Remodeling domain interfaces to enhance heterodimer formation
Zhenping Zhu et al.
PROTEIN SCIENCE (2010)
General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
Cecile Vincke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic CD28 stimulation and killing of lymphoma cells
T. Otz et al.
LEUKEMIA (2009)
Autoimmune diseases induced by TNF-targeted therapies
Manuel Ramos-Casals et al.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2008)
Interaction of Human C1q with IgG and IgM: Revisited
Mihaela G. Gadjeva et al.
BIOCHEMISTRY (2008)
Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities
Akito Natsume et al.
CANCER RESEARCH (2008)
Central nervous system therapy for lysosomal storage disorders
Gregory M. Enns et al.
NEUROSURGICAL FOCUS (2008)
Distinct structural and adhesive roles of Ca2+ in membrane binding of blood coagulation factors
Y. Zenrnei Ohkubo et al.
STRUCTURE (2008)
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
Chengbin Wu et al.
NATURE BIOTECHNOLOGY (2007)
Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating fcγ receptors
Jeffrey B. Stavenhagen et al.
CANCER RESEARCH (2007)
A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects
Scott E. Strome et al.
ONCOLOGIST (2007)
Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics
Jennifer A. MacDiarmid et al.
CANCER CELL (2007)
CD19/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis
Michael Molhoj et al.
MOLECULAR IMMUNOLOGY (2007)
Engineered antibody Fc variants with enhanced effector function
GA Lazar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A revival of bispecific antibodies
P Kufer et al.
TRENDS IN BIOTECHNOLOGY (2004)
Alternatively spliced isoforms of fibronectin in immune-mediated glomerulosclerosis:: the role of TGFβ and IL-4
HJ Baelde et al.
JOURNAL OF PATHOLOGY (2004)
Contributions of CDR3 to VHH domain stability and the design of monobody scaffolds for naive antibody libraries
CJ Bond et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs inVL-to-VH orientation:: Implications for diabody flexibility
JA Carmichael et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Pretargeting for cancer radioimmunotherapy with bispecific antibodies: Role of the bispecific antibody's valency for the tumor target antigen
H Karacay et al.
BIOCONJUGATE CHEMISTRY (2002)
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
DB Agus et al.
CANCER CELL (2002)
Optimal design features of camelized human single-domain antibody libraries
J Tanha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity
AM McCall et al.
JOURNAL OF IMMUNOLOGY (2001)
High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR
RL Shields et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Bispecific human IgG by design
P Carter
JOURNAL OF IMMUNOLOGICAL METHODS (2001)
Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc
EE Idusogie et al.
JOURNAL OF IMMUNOLOGY (2000)