Journal
SCIENCE
Volume 290, Issue 5497, Pages 1717-1721Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5497.1717
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Funding
- NCI NIH HHS [CA58689] Funding Source: Medline
- NIGMS NIH HHS [R01 GM053396, GM53396, R01 GM053396-11] Funding Source: Medline
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Macroautophagy is a dynamic process involving the rearrangement of subcellular membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole where the sequestered cargo is degraded and recycled. This profess takes place in ail eukaryotic cells. It is highly regulated through the action of various kinases, phosphatases, and guanosine triphosphatases (GTPases). The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway includes a ubiquitin-like protein conjugation system and a protein complex that directs membrane docking and fusion at the Lysosome or vacuole. Macroautophagy plays an important role in developmental processes, human disease, and cellular response to nutrient deprivation.
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