Journal
BIODRUGS
Volume 28, Issue 3, Pages 265-274Publisher
ADIS INT LTD
DOI: 10.1007/s40259-013-0081-y
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Funding
- National Natural Science Foundation [81371851, 81071316, 81271882]
- National Megaprojects for Key Infectious Diseases [2008ZX10003-006]
- New Century Excellent Talents in Universities [NCET-11-0703]
- Southwest University [kb2010017, ky2011003]
- Fundamental Research Funds for the Central Universities [XDJK2011D006, XDJK2012D011, XDJK2012D007, XDJK2013D003]
- Natural Science Foundation Project of CQ CSTC [CSTC 2010BB5002]
- Chongqing Municipal Committee of Education for Postgraduates Excellence Program [YJG123104]
- Undergraduates Teaching Reform Program [2011JY052]
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Polysaccharide depolymerase, a polysaccharide hydrolase encoded by bacteriophages (or 'phages'), can specifically degrade the macromolecule carbohydrates of the host bacterial envelope. This enzyme assists the bacteriophage in adsorbing, invading, and disintegrating the host bacteria. Polysaccharide depolymerase activity continues even within biofilms. This effectiveness means phages are promising candidates for novel antibiotic scaffolds. A comprehensive compendium of bacteriophage polysaccharide depolymerases has been compiled, together with their potential biomedical applications, such as novel antibiotics, adjuvants for antibiotics, bacterial biofilm disruptants, and diagnostic kits.
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