Journal
BIODRUGS
Volume 27, Issue 1, Pages 55-67Publisher
ADIS INT LTD
DOI: 10.1007/s40259-012-0007-0
Keywords
-
Categories
Funding
- Digestive Disease Research Center (DDRC) at Tehran University of Medical Sciences
- Research Center for Pharmaceutical Nanotechnology (RCPN) at Tabriz University of Medical Sciences
Ask authors/readers for more resources
Background and Objective Gastric/gastrointestinal cancers are associated with high mortality worldwide. G-protein coupled receptor (GPCR) superfamily members such as gastrin/cholecystokinin-B receptor (CCK-BR) are involved in progression of gastric tumors, thus CCK-BR is considered as a potential target for immunotherapy. However, production of functional monoclonal antibodies (mAbs) against GPCR seems to be very challenging, in part due to its integration in cell membranes and inaccessibility for selection. To tackle this problem, we implemented phage display technology and a solution-phase biopanning (SPB) scheme for production of mAbs specific to the native conformation of CCK-BR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available