Journal
IMMUNOLOGY TODAY
Volume 21, Issue 12, Pages 611-614Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0167-5699(00)01745-X
Keywords
-
Categories
Ask authors/readers for more resources
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available