Journal
MOLECULAR CELL
Volume 6, Issue 6, Pages 1389-1399Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(00)00136-2
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Funding
- NICHD NIH HHS [R01 HD036437-03, R01 HD036437-02, R01 HD036437-04] Funding Source: Medline
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Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis.
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