Journal
ENDOSCOPY
Volume 32, Issue 12, Pages 921-930Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2000-9626
Keywords
-
Categories
Funding
- NCI NIH HHS [9-RO1-CA75289-03] Funding Source: Medline
- NEI NIH HHS [9-RO1-EY11289-14] Funding Source: Medline
- NIAMS NIH HHS [R01-AR44812-02] Funding Source: Medline
Ask authors/readers for more resources
Background and Study Aims: Endoscopic optical coherence tomography (OCT) is an emerging medical technology capable of generating high-resolution cross-sectional imaging of tissue microstructure in situ and in real time, We assess the use and feasibility of OCT for real-time screening and diagnosis of Barrett's esophagus, and also review state-of-the-art OCT technology for endoscopic imaging. Materials and Methods: OCT imaging was performed as an adjunct to endoscopic imaging of the human esophagus, Real-time OCT (13-mum resolution) was used to perform image-guided evaluation of normal esophagus and Barrett's esophagus, Beam delivery was accomplished with a l-mm diameter OCT catheter-probe that can be introduced into the accessory channel of a standard endoscope, Different catheter-probe imaging designs which performed linear and radial scanning were assessed, Novel ultrahigh-resolution (1.1 mum resolution) and spectroscopic OCT techniques were used to image in vitro specimens of Barrett's esophagus. Results: Endoscopic OCT images revealed distinct layers of normal human esophagus extending from the epithelium to the muscularis propria, In contrast, the presence of gland- and crypt-like morphologies and the absence of layered structures were observed in Barrett's esophagus, All OCT images showed strong correlations with architectural morphology in histological findings, Ultrahigh-resolution OCT techniques achieved 1.1 mum image resolution in in vitro specimens and showed enhanced resolution of architectural features. Spectroscopic OCT identified localized regions of wavelength-dependent optical scattering, enhancing the differentiation of Barrett's esophagus. Conclusions: OCT technology with compact fiberoptic imaging probes can be used as an adjunct to endoscopy for real-time image-guided evaluation of Barrett's esophagus. Linear and radial scan patterns have different advantages and limitations depending upon the application, Ultrahigh-resolution and spectroscopic OCT techniques improve structural tissue recognition and suggest future potential for resolution and contrast enhancements in clinical studies, A new balloon catheter-probe delivery device is proposed for systematic imaging and screening of the esophagus.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available