Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 44, Issue 12, Pages 3441-3443Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.44.12.3441-3443.2000
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Funding
- NIAID NIH HHS [R37 AI009644, R01 AI009644, AI09644] Funding Source: Medline
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Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by greater than or equal to 170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, greater than or equal to 32 mug/ml) but not in any of the 15 isolates for which the MIC was less than or equal to1 mug/ml.
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