Journal
SCIENCE
Volume 290, Issue 5497, Pages 1779-1782Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5497.1779
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- NIAID NIH HHS [AI30656] Funding Source: Medline
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Bone marrow stern cells give rise to a variety of hematopoietic Lineages and repopulate the blood throughout adult Life. We show that, in a strain of mice incapable of developing colts of the myeloid and Lymphoid lineages,transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.
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