Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 119, Issue 4, Pages 464-469Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2014.09.008
Keywords
Polygonum cuspidatum; Supercritical fluid carbon dioxide extraction; Antioxidant; Anti-tyrosinase; Immune; Anti-cancer
Funding
- National Science Council of Taiwan, ROC
- Derlin Biotech Corp. [102-2622-E-037-001-CC2]
- Ministry of Health and Welfare [MOHW103-TD-B-111-05]
- [NSC102-2622-E-037-002]
- [NSC 102-2221-E-037-005]
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In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We developed bioactive effects of P. cuspidatum extracts via multiple examinations that established bio-purposes at a range of dosage ranges. The research of P. cuspidatum extracts indicated that they possessed anti-oxidative properties on radical-scavenging abilities, reducing activities and metal chelating powers in dose-dependant manners. The extracts also had minor in vitro mushroom tyrosinase suppression and decreased cellular tyrosinase activities and melanin production in B16-F10 cells. Immunologically, P. cuspidatum extracts enhanced the release of tumor necrosis factor alpha (TNF-alpha) induced by THP-1 macrophage cell line. In addition, the cell proliferation showed anti-proliferation in dose-dependent manner on human skin melanoma cells, A375 and A375.S2, of the extracts suggesting biological constitutes employed the anti-cancer possessions. This is the first statement presenting bioactivities on P. cuspidatum extracts including anti-oxidation, immune stimulation, anti-tyrosinase and anti-melanoma as far as we know. (C) 2014, The Society for Biotechnology, Japan. All rights reserved.
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