Journal
ANALYST
Volume 140, Issue 16, Pages 5634-5639Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an00741k
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Funding
- National Natural Science Foundation of China [50925207, 51432006]
- Ministry of Science and Technology of China for the International Science Linkages Program [2011DFG52970]
- Natural Science Foundation of Jiangsu Province, China [BK20140157]
- Programme of Introducing Talents of Discipline to Universities (111 Project) [B13025]
- Fundamental Research Funds for the Central Universities [JUSRP11418]
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A one-pot sonochemical reaction of Cu(NO3)(2) with glutathione (GSH), the latter functioning as a reducing agent and a stabilizing agent, rapidly affords Cu nanoclusters (NCs). The as-prepared GSH-CuNCs possess a small size (similar to 2.2 +/- 0.2 nm), red luminescence with quantum yield (5.3%), and water-dispersibility. Moreover, the fluorescence of the as-prepared GSH-CuNCs is responsive to pH so that the intensity of fluorescence increases rapidly with decreasing pH from 9 to 4. Besides, the GSH-CuNCs would be aggregated by Pb2+ ions in aqueous solution which results in quenching of the fluorescence. Therefore, such GSH-CuNCs would be excellent candidates as fluorescent probes for the label-free detection of Pb2+ with the limit of detection at 1.0 nM. Importantly, CAL-27 cells are used as models to achieve potential application as probes for monitoring Pb2+ in living cells. Thus, these fluorescent CuNCs could work as an alternative to conventional fluorescent probes for biolabeling, sensing and other applications.
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