Journal
JOURNAL OF BACTERIOLOGY
Volume 182, Issue 23, Pages 6824-6826Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.23.6824-6826.2000
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Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma (B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma (B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma (B) in S. aureus biofilm regulation under environmental stress conditions.
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