Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 129, Issue 1-2, Pages 77-97Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0009-2797(00)00199-X
Keywords
NQO1 (NAD(P)H : quinone oxidoreductase 1); quinone; vitamin E; ubiquinone; antitumor quinones; gene regulation; antioxidant response element (ARE) polymorphisms
Funding
- NCI NIH HHS [CA51210] Funding Source: Medline
- NIEHS NIH HHS [ESO9954] Funding Source: Medline
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NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones, This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of antioxidant forms of ubiquinone and vitamin E, Bioactivation reactions catalyzed by NQO1 are also summarized and the development of new antitumor agents for the therapy of solid tumors with marked NQO1 content is reviewed. NQO1 gene regulation and the role of the antioxidant response element and the xenobiotic response element in transcriptional regulation is summarized. An overview of genetic polymorphisms in NQO1 is presented and biological significance for chemoprotection, cancer susceptibility and antitumor drug action is discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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