Molecular crosstalk in host-parasite relationships: Schistosome- and leech-host interactions

The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. In this context, parasites often use the same or similar immune signaling molecules and/or molecular mimicry to escape host immunosurveillance. Both processes represent an adaptive strategy to ensure host immunocompatibility. This bidirectional communication between parasites and their hosts includes the renin-angiotensin, opioid and opiate systems. Here, Michel Salzet, Andre Capron and George Stefano review recent work on the interaction of common signaling mechanisms in schistosomes, leeches and their host.