Journal
NATURE IMMUNOLOGY
Volume 1, Issue 6, Pages 469-474Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/82712
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Originally identified as a cell surface receptor that triggered the death of lymphocytes and tumor cells, it is now recognized that pas (also known as CD95 or Apo-I) has distinct functions in the life and death of different cell types in the immune system, pas signaling may also be involved in T cell costimulation and proliferation. Although pas deficiency in humans and mice predisposes them towards systemic autoimmunity, Fas-FasL interactions can also facilitate organ-specific immunopathology. Proximal signaling by pas and related receptors depends on subunit preassembly, which accounts for the dominant-negative effect of pathogenic receptor mutants and natural splice variants.
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