Journal
JOURNAL OF NATURAL PRODUCTS
Volume 63, Issue 12, Pages 1603-1607Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000271n
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Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3-5 were found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 cancer cell lines.
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