Journal
PHYTOCHEMISTRY
Volume 55, Issue 8, Pages 903-908Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(00)00254-5
Keywords
Centaurea thessala ssp drakiensis; Centaurea attica ssp attica; Asteraceae; sesquiterpene lactones; germacranolides; elemanolides; eudesmanolides; eudesmane derivative; antifungal activity
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The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
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