Journal
NEURON
Volume 28, Issue 3, Pages 753-766Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(00)00151-3
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Funding
- NINDS NIH HHS [NS18366] Funding Source: Medline
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Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia. In robe mutants, growth cones cross and recross the midline, while, in slit mutants, growth cones enter the midline but fail to leave it. This difference suggests that Slit must have more than one receptor controlling midline guidance. In the absence of Robe, some other Slit receptor ensures that growth cones do not stay at the midline, even though they cross and recross it. Here we show that the Drosophila genome encodes three Robe receptors and that Robe and Robo2 have distinct functions, which together control repulsive axon guidance at the midline. The robo,robo2 double mutant is largely identical to slit.
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