Journal
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 107, Issue 12, Pages 1513-1515Publisher
ELSEVIER
DOI: 10.1111/j.1471-0528.2000.tb11677.x
Keywords
-
Categories
Ask authors/readers for more resources
Effects of folate deficiency on the rate of apoptosis in human cytotrophoblastic cells has been investigated. Apoptosis was determined in cytotrophoblastic cells after culture in 1. control medium, 2. folate-free medium and 3. folate-free medium plus 10% fetal calf serum. Apoptosis rates in cells cultured in mediums 2 and 3 were significantly higher than those cultured in the control medium (P < 0.02 and P < 0.03, respectively). In conclusion, human cytotrophoblastic cells show a significantly increased rate of apoptosis in vitro after culture in a folate-free medium. Possible explanations for the association between folate deficiency and pregnancy complications are suggested.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available