Journal
MECHANISMS OF DEVELOPMENT
Volume 99, Issue 1-2, Pages 183-186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00478-0
Keywords
zebrafish; caudal fin; regeneration; development; Hsp40; wound healing; blastema; chaperones; Hsc70; heat shock proteins; osteoblasts
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We report the characterization of a zebrafish DnaJ-like protein, homologue to the human Hsp40 protein hdj1, that we named zf-Hsp40. We have studied its expression during fin regeneration and we show that zf-Hsp40 mRNA level is drastically increased in all ray segments beneath the regenerated part, or blastema, in response to caudal fin amputation. In order to investigate whether zf-Hsp40 is part of a stress response system after injury, we studied the expression of the zebrafish Hsc70 transcript. Our results show a correlation between the expression of the two transcripts. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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