Journal
JOURNAL OF BIOPHOTONICS
Volume 8, Issue 9, Pages 765-774Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400131
Keywords
photodynamic treatment; photofrin; gap junction intercellular communication; reactive oxygen species; calcium; hela cell line
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Funding
- National Natural Science Foundation of China [81373439, 81402946]
- Joint Fund of the National Nature Science Foundation of China [U1303221]
- Department of Science and Technology of Xinjiang province [201233150]
- Department of Science and Technology of Guangzhou, China [201300000158]
- Guangdong Natural Science Foundation [S2013010016435]
- Natural Science Research grant of Higher Education of Jiangsu province, China [14KJD310002]
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Despite initially positive responses, recurrences after Photodynamic treatment (PDT) can occur and there is need for improvement in the effectiveness of PDT. Our study uniquely showed that there was a significantly gap junctional intercellular communication (GJIC)-dependent PDT cytotoxicity. The presence of GJIC composed of Connexin 32 increased the PDT phototoxicity in transfected HeLa cells and in the xenograft tumors, and the enhanced phototoxicity of Photofrin-mediated PDT by GJIC was related with ROS and calcium pathways. Our study indicates the possibility that up-regulation or maintenance of gap junction functionality may be used to increase the efficacy of PDT. [GRAPHICS] The phototoxicity effect of Photofrin was substantially greater in Dox-treated cells, which expressed the Cx32 and formed the GJ, than Dox-untreated.
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