Journal
BRAIN RESEARCH
Volume 885, Issue 1, Pages 117-121Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02984-X
Keywords
microglia; blood vessel; amyloid beta-protein; inflammation
Categories
Ask authors/readers for more resources
We have investigated immunohistochemically the expression of CD40 in post-mortem human brain tissues. In control brain, the blood vessels were stained weakly for CD40. Vascular expression of CD40 was enhanced in the lesions of Alzheimer's disease and some other neurological diseases. In such diseases, reactive microglia were also positive for CD40. The results of this study suggest that CD40 expression by microglia is up-regulated upon a variety of brain insults and is not limited to lesions with amyloid beta -protein deposits. (C) 2000 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available