Journal
FASEB JOURNAL
Volume 14, Issue 15, Pages 2459-2465Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.00-0205rev
Keywords
VMAT2; serotonin; histamine; dopamine; norepinephrine; synaptic vesicle; Parkinsonism; MPTP
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Monoamine compartmentalization in monoaminergic neurons uses serial action of the plasma membrane and vesicular monoamine (VAMT2) transporters. We can now define the sequences of the genes encoding these transporters in mice and humans, examine influences of deletions of this gene and alteration in its expression levels in transgenic mice, and identify sequence polymorphisms in the human VMAT2 gene. Examination of VMAT2 variants can provide potential insights into roles for allelic variants at these loci in variant drug responses and in diseases linked to monoaminergic systems, including substance abuse and Parkinson's disease.
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