Journal
NATURE CELL BIOLOGY
Volume 2, Issue 12, Pages E231-E236Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35046659
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Funding
- NIGMS NIH HHS [R01 GM047607] Funding Source: Medline
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To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.
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