Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 12, Issue 6, Pages 697-704Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(00)00154-X
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Funding
- NIGMS NIH HHS [GM53194] Funding Source: Medline
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In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice, in addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.
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