4.7 Article

Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 63, Issue 12, Pages 1692-1695

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np0002942

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Funding

  1. NCI NIH HHS [CA67786] Funding Source: Medline
  2. NIGMS NIH HHS [GM08500] Funding Source: Medline

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Three new cytotoxic cytochalasins (1-3) and the previously reported cytochalasin E (4) were isolated from a culture of the endophytic fungus Rhinocladiella sp. using bioassay-guided fractionation. Extensive NMR and HRCIMS experiments identified these new compounds as 22-oxa-[12]-cytochalasins.

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