Journal
CYTOKINE
Volume 12, Issue 12, Pages 1793-1796Publisher
W B SAUNDERS CO
DOI: 10.1006/cyto.2000.0786
Keywords
coxsackie B virus; cytokine; enterovirus; poliovirus
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Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induce production of pro-inflammatory cytokines IL-1 beta and TNF-alpha in freshly isolated human leucocytes. Furthermore, enteroviruses stimulate the production of cytokines belonging to Th-1 pathways (IFN-gamma, IL-2), and IL-10, which play a role in regulation of the cellular and humoral immune response. (C) 2000 Academic Press.
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