Journal
NEUROSCIENCE LETTERS
Volume 295, Issue 1-2, Pages 67-69Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01590-1
Keywords
anoxia; brainstem-spinal cord; in vitro; neonatal rat; parapyramidal area; respiratory rhythm; retrotrapezoid nucleus
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The brainstem-spinal cord preparation from neonatal rat has been used in several reports to evaluate the central effect of low oxygen level on the respiratory network. We demonstrate that bilateral lesion of retrotrapezoid nucleus and parapyramidal area unmasks an early reinforcement of the respiratory output in response to anoxia. This suggests that neurons in both areas might trigger or relay a central depressive influence of hypoxia on the respiratory network. (C) 2000 Published by Elsevier Science ireland Ltd.
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