Journal
BIOLOGICAL PSYCHIATRY
Volume 48, Issue 11, Pages 1045-1052Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(00)00962-8
Keywords
bipolar disorder; mania; affective disorders; tomography emission-computed; gyrus cinguli; caudate nucleus
Categories
Ask authors/readers for more resources
Background: Executive control of cognition, emotion, and behavior are disrupted in the manic state of bipolar disorder. Whereas frontal systems are implicated in such dysfunction, the localization of functional brain abnormalities in the manic state is not well understood. Methods: We utilized a high-sensitivity (H2O)-O-15 positron emission tomography technique to investigate regions of increased brain activity in mania, compared to euthymia, in bipolar disorder, Results: The principal findings were manic state-related increased activity in left dorsal anterior cingulate, and left head of caudate, Conclusions: The findings suggest that the manic state of bipolar disorder may be associated with heightened activity in a frontal cortical-subcortical neural system that includes the anterior cingulate and caudate, (C) 2000 Society of Biological Psychiatry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available