Journal
JOURNAL OF BIOPHOTONICS
Volume 9, Issue 3, Pages 260-269Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201500109
Keywords
anti-glomerular basement membrane nephritis; acute nephritis; optical diagnosis; Raman spectroscopy; principal component analysis; linear discriminant analysis
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Funding
- National Science Foundation (NSF) CAREER Award [CBET-1151154]
- National Aeronautics and Space Administration (NASA) Early Career Faculty Grant [NNX12AQ44G]
- Gulf of Mexico Research Initiative [GoMRI-030]
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Both acute nephritis and chronic nephritis account for substantial morbidity and mortality worldwide, partly due to the lack of reliable tools for detecting disease early and monitoring its progression non-invasively. In this work, Raman spectroscopy coupled with multivariate analysis are employed for the first time to study the accelerated progression of nephritis in anti-GBM mouse model. Preliminary results show up to 98% discriminant accuracy for the severe and midly diseased and the healthy among two strains of mice with different susceptibility to acute glomerulonephritis. This technique has the potential for noninvasive or minimally-invasive early diagnosis, prognosis, and monitoring of renal disease progression.
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