Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 11, Issue 10, Pages 416-420Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1043-2760(00)00310-6
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The D allele of the angiotensin-converting enzyme (ACE) I/D polymorphism is associated with elevated levels of serum and tissue ACE, increased production of the vasopressor angiotensin II and a reduction in the half-life of the vasodilator bradykinin. Several cardiac and venal conditions appear to have a worse prognosis in subjects homozygous for the D allele, whereas the I allele has been associated with enhanced endurance performance in elite distance runners, rowers avid mountaineers. The nature of the gene-environment interaction between ACE I/D polymorphisms and physical training, an overview of recent findings and a discussion of possible underlying mechanisms is the subject of this review.
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