Journal
JOURNAL OF BIOPHOTONICS
Volume 9, Issue 3, Pages 235-245Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201500151
Keywords
hyperspectral imaging; specular reflection detection; endoscopy; in-vivo; larynx; image processing
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Funding
- German Cancer Aid as part of the project Early Detection of Laryngeal Cancer by Hyperspectral Imaging [109825, 110275]
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Hyperspectral imaging (HSI) is a technology with high potential in the field of non-invasive detection of cancer. However, in complex imaging situations like HSI of the larynx with a rigid endoscope, various image interferences can disable a proper classification of cancerous tissue. We identified three main problems: i) misregistration of single images in a HS cube due to patient heartbeat ii) image noise and iii) specular reflections (SR). Consequently, an image pre-processor is developed in the current paper to overcome these image interferences. It encompasses i) image registration ii) noise removal by minimum noise fraction (MNF) transformation and iii) a novel SR detection method. The results reveal that the pre-processor improves classification performance, while the newly developed SR detection method outperforms global thresholding technique hitherto used by 46%. The novel pre-processor will be used for future studies towards the development of an operational scheme for HS-based larynx cancer detection.
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