Journal
BIOCONJUGATE CHEMISTRY
Volume 25, Issue 9, Pages 1655-1663Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc500279w
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Funding
- National Natural Science Foundation for Distinguished Young Scholars [81225011]
- State Key Program of National Natural Science of China [81230036]
- National Natural Science Foundation of China [81371580, 21273014]
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This paper reported a core-shell nanotheranostic agent by growing Prussian blue (PB) nanoshells of 3-6 nm around superparamagnetic Fe3O4 nanocores for targeted photothermal therapy of cancer under magnetic resonance imaging (MRI) guidance. Both in vitro and in vivo experiments proved that the Fe3O4@PB core-shell nanoparticles showed significant contrast enhancement for T-2-weighted MRI with the relaxivity value of 58.9 mM(-1).s(-1). Simultaneously, the composite nanoparticles exhibited a high photothermal effect under irradiation of a near-infrared laser due to the strong absorption of PB nanoshells, which led to more than 80% death of HeLa cells with only 0.016 mg.mL(-1) of the nanoparticles with the aid of the magnetic targeting effect. Using tumor-bearing nude mice as the model, the near-infrared laser light ablated the tumor effectively in the presence of the Fe3O4@PB nanopartides and the tumor growth inhibition was evaluated to be 87.2%. Capabilities of MRI, magnetic targeting, and photothermal therapy were thus integrated into a single agent to allow efficient MRI-guided targeted photothermal therapy. Most importantly, both PB and Fe3O4 nanoparticles were already clinically approved drugs, so the Fe3O4@PB nanopartides as a theranostic nanomedicine would be particularly promising for clinical applications in the human body due to the reliable biosafety.
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