Journal
BIOCONJUGATE CHEMISTRY
Volume 24, Issue 5, Pages 735-765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc300516f
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Funding
- French Ministry of Research
- EEC
- CNRS
- Institut Pasteur de Lille
- Univ. Lille Nord de France
- Region Nord Pas-de-Calais
- Canceropole Nord-Ouest
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Since the 1990s, alpha-oxo aldehyde or glyoxylic acid chemistry has inspired a vast array of synthetic tools for tailoring peptide or protein structures, for developing peptides endowed with novel physicochemical properties or biological functions, for assembling a large diversity of bioconjugates or hybrid materials, or for designing peptide-based micro or nanosystems. This past decade, important developments have enriched the alpha-oxo aldehyde synthetic tool box in peptide bioconjugation chemistry and explored novel applications. The aim of this review is to give a large overview of this creative field.
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