Journal
BIOCONJUGATE CHEMISTRY
Volume 24, Issue 11, Pages 1828-1839Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc400170r
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Funding
- CSIR
- DBT
- Singapore National Research Foundation Fellowship [NRF2009NRFRF001-015]
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We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) nuclear-targeted nanocarrier for drug delivery, (ii) phototrigger for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of similar to 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release.
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