Journal
SCIENCE
Volume 290, Issue 5497, Pages 1775-1779Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5497.1775
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Funding
- NCI NIH HHS [CA59717] Funding Source: Medline
- NIA NIH HHS [AG09521] Funding Source: Medline
- NICHD NIH HHS [HD18179] Funding Source: Medline
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After intravascular delivery of genetically marked adult mouse bone marrow into Lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes) developed in the central nervous system. Flow cytometry revealed a population of donor-derived cells in the brain with characteristics distinct from bone marrow. Confocal microscopy of individual cells showed that hundreds of marrow-derived cells in brain sections expressed gene products typical of neurons (NeuN, 200-kilodalton neurofilament, and class III beta -tubulin) and were able to activate the transcription factor CAMP response element-binding protein (CREB). The generation of neuronal phenotypes in the adult brain 1 to 6 months after an adult bone marrow transplant demonstrates a remarkable plasticity of adult tissues with potential clinical applications.
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