Journal
PLANTA MEDICA
Volume 66, Issue 8, Pages 768-769Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2000-9601
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Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var, heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3 beta -O-trans-p-coumaroyl alphitolic acid 3, 3 beta -O-cis-p-coumaroyl alphitolic acid 4, 3 beta -O-trans-p-coumaroyl maslinic acid 5, 3 beta -O-cis-p-coumaroyl maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method. Compounds 2, 3, 5, and 6 showed antimicrobial activity on Cram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.
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