Journal
CURRENT OPINION IN NEUROLOGY
Volume 13, Issue 6, Pages 721-727Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00019052-200012000-00018
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Evidence from both biochemical measurements and from noninvasive techniques continues to suggest that neurotransmission failure rather than primary energy failure is the major cause of hepatic encephalopathy. Major neurotransmitter systems in which abnormalities have been identified include the glutamatergic, monoaminergic and opioid systems. Further elucidation of these neurotransmitter changes could provide novel pharmacological approaches in the treatment of hepatic encephalopathy. Curr Opin Neurol 13:721-727. (C) 2000 Lippincott Williams & Wilkins.
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