Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 100, Issue 2, Pages 75-80Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0925-4927(00)00073-1
Keywords
brain perfusion; major depression; left dorsolateral prefrontal cortex; Tc-99m-hexamethylpropyleneamine oxime; SPECT
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Changes of regional cerebral blood flow (rCBF) in five drug-resistant depressed patients were examined by single photon emission computed tomography (SPECT) with Tc-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) before and after treatment with transcranial magnetic stimulation (TMS). The SPECT images were analysed with the Statistical Parametric Mapping (SPM) package. TMS administered in the region of the left dorsolateral prefrontal cortex (DLPFC) of the depressed patients was associated with an increase of rCBF at a focal region some distance from the stimulation site. No change was observed at any other remote region. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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