Journal
BIOCONJUGATE CHEMISTRY
Volume 23, Issue 8, Pages 1503-1506Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc300182y
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [23390009, 22700489, 11J08644] Funding Source: KAKEN
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Herein, we report a unique technique to accelerate polymer-SNA conjugation based on copper free click chemistry: gradual freeze thawing of the reaction solution substantially increases the conjugation rate possibly because of the reactant concentration at the microenvironment scale. This technique was applied to the conjugation between a small interfering RNA (siRNA) and PEG in an aqueous buffer at/below room temperature.
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