Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 23, Pages 2613-2616Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00528-X
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Funding
- NCI NIH HHS [CA42056] Funding Source: Medline
- NIDA NIH HHS [R01 DA015648] Funding Source: Medline
- NIMH NIH HHS [MH58542, R01 MH058542-04] Funding Source: Medline
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Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd. All rights reserved.
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