Palladium-catalyzed coupling reaction of fluoroalkylated propargyl mesylates with organozinc reagents: Novel synthesis of optically active fluorine-containing trisubstituted allenes

In the presence of 5 mol% of tetrakis(triphenylphosphine)palladium(0). the reaction of chiral fluorinated propargyl mesylates with a variety of organozinc reagents proceeded smoothly in a highly stereoselective fashion to give the corresponding optically active fluorine-containing trisubstituted allenes in good yields without any loss of optical purity through the reaction.