Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 116, Issue 2, Pages 141-148Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0166-4328(00)00275-8
Keywords
traumatic brain injury; progesterone; pseudopregnant; sex differences; sensorimotor; forelimb use; foot fault; recovery
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We studied sensorimotor recovery in male, normal-cycling and pseudopregnant female rats following unilateral FL-SMC contusions. Forelimb use (push off before a rear, support against the walls, and landing after a rear) and the foot fault test (foot misplacements during locomotion on an elevated grid) were analyzed from videotapes taken before surgery, and then again on post-surgical days 2 and 36. High endogenous progesterone levels in females at the time of injury did not affect recovery as there were no differences between males, pseudopregnant females and normal-cycling female rats on these behaviors. None of the brain-injured rats recovered symmetrical forelimb use between 2 and 36 days after injury (P > 0.05) and they also showed foot misplacements (P > 0.05) in the foot fault test. Male and female rats with contusions had fewer mean foot misplacements on day 36 than 2 days after injury (P < 0.001), indicating that there was partial recovery on this task. These results were taken to show that there were no sex differences in motor deficits caused by unilateral FL-SMC injury. In addition, higher endogenous progesterone levels in females did not protect them from the chronic sensorimotor deficits caused by unilateral FL-SMC contusions. (C) 2000 Elsevier Science B.V. All rights reserved.
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