Journal
MOLECULAR BRAIN RESEARCH
Volume 84, Issue 1-2, Pages 141-145Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(00)00236-9
Keywords
Sox10; inner ear; cochlea; organ of Corti; supporting cell; otic vesicle
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Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V. All rights reserved.
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