Journal
BIOCONJUGATE CHEMISTRY
Volume 22, Issue 6, Pages 1056-1065Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc100542r
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Funding
- National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268201000043C]
- Frechet fund
- Deutsche Forschungsgemeinschaft (DFG)
- Alexander von Humboldt Foundation (AvH)
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We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.
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