Journal
SCIENCE
Volume 290, Issue 5498, Pages 1975-1978Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5498.1975
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Funding
- NIGMS NIH HHS [GM49782] Funding Source: Medline
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Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.
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